Practical-Tablet Making Lab Report Example | Topics and Well Written Essays - 750 words

Practical-Tablet Making - Lab Report Example HPLC assay was also done to assess the actual concentration (correct amount) of paracetamol’s active compound (acetaminophen) present in selected tablets. Table one below shows the two drug formulation used in the experiment, the tables, were tested for appearance, weight, hardness, thickness, diameter, and friability. The tablets were assessed for physical appearance by observing them through a magnifying glass. The size (diameter and thickness), weight, and hardness were determined using micrometre screw gauge, digital balance, and schleuniger hardness tester respectively. The tablets from either of the formulation compositions were found to have a uniform round and white appearance. In addition, formulation 1 b tablets were larger with a matte appearance than those of formulation 2 that were generally small in size and with a glossy appearance. No imperfections (groves) were noted on any of the tablets even after observing them using magnifying glass. A consistent difference in weight and diameter was also noted between the two formulations, with the formulation 1b having a median weight and diameter of 2.961g and 25.66mm respectively. However, there was no difference in thickness noted between tablets of the two formulations. Table 2 and 3 below provides a summary of the average, RSD, minimum and maximum weight, diameter, hardness, and thickness values of the two tablet formulations. In determining friability (percentage loss in weight), the total weight of the five tablets was used in the analysis. The tablets were tested for friability by using the Copley friability tester at a testing speed of 25 revolutions per minute (RPM). The total percentage loss in weight of the five tablets from each formulation was calculated and summarized in table 4 below. It is important to note that formula 2 tablets had a friability